Napnoll-D 500 Tablet is a combination of two medications used to prevent migraines by blocking pain, inflammation, and fever-causing chemical messengers and brain signals. It can be taken alone or with food, and the dose depends on the severity of the condition. Common side effects include flu-like symptoms, indigestion, and dry mouth. Patients should inform their doctor about other illnesses, other medications, and their condition. Napnoll-D 500 Tablet should be used cautiously in patients with alcoholics, liver or kidney disease, and pregnant or breastfeeding women.