Isotrenol-10 Capsule is a retinoid medication used to treat severe acne. It should be taken as directed by your doctor, with food, and should be taken regularly. Common side effects include dry skin, rash, and increased liver enzymes. It may increase sensitivity to sunlight and make skin more fragile. It may also cause dryness in the mouth, lips, and eyes. Pregnant or planning pregnant individuals should consult their doctor about potential birth defects.